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Trancriptional regulation of the NKT cell lineage
How expression of canonical semi-invariant TCRs leads to innate-like effector differentiation is a central enigma of NKT cell development. NKT thymic precursors undergo elevated TCR signals leading to increased Egr2, which directly induces their signature transcription factor, PLZF. PLZF is necessar...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3647452/ https://ncbi.nlm.nih.gov/pubmed/23402834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coi.2013.01.003 |
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