IL-15 AGONISTS OVERCOME THE IMMUNOSUPPRESSIVE EFFECTS OF MEK INHIBITORS

Many signal transduction inhibitors being developed for cancer therapy target pathways that are also important for the proper function of anti-tumor lymphocytes, possibly weakening their therapeutic effects. Here we show that most inhibitors targeting multiple signaling pathways have especially stro...

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Publié dans:Cancer Res
Auteurs principaux: Allegrezza, Michael J., Rutkowski, Melanie R., Stephen, Tom L., Svoronos, Nikolaos, Tesone, Amelia J., Perales-Puchalt, Alfredo, Nguyen, Jenny M., Sarmin, Fahmida, Sheen, Mee Rie, Jeng, Emily K., Tchou, Julia, Wong, Hing C., Fiering, Steven, Conejo-Garcia, Jose R.
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873368/
https://ncbi.nlm.nih.gov/pubmed/26980764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2808
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