MICROBIAL DRIVEN TLR5-DEPENDENT SIGNALING GOVERNS DISTAL MALIGNANT PROGRESSION THROUGH TUMOR-PROMOTING INFLAMMATION

The dominant TLR5(R392X) polymorphism abrogates flagellin responses in >7% of humans. We report that TLR5-dependent commensal bacteria drive malignant progression at extra-mucosal locations by increasing systemic IL-6, which drives mobilization of myeloid derived suppressor cells (MDSCs). Mechani...

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Udgivet i:Cancer Cell
Main Authors: Rutkowski, Melanie R., Stephen, Tom L., Svoronos, Nikolaos, Allegrezza, Michael J., Tesone, Amelia J., Perales-Puchalt, Alfredo, Brencicova, Eva, Escovar-Fadul, Ximena, Nguyen, Jenny M., Cadungog, Mark G., Zhang, Rugang, Salatino, Mariana, Tchou, Julia, Rabinovich, Gabriel A., Conejo-Garcia, Jose R.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4293269/
https://ncbi.nlm.nih.gov/pubmed/25533336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2014.11.009
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