TRANSFORMING GROWTH FACTOR-BETA MEDIATED SUPPRESSION OF ANTI-TUMOR T CELLS REQUIRES FOXP1 TRANSCRIPTION FACTOR EXPRESSION

Tumor-reactive T cells become unresponsive in advanced tumors. Here we have characterized a common mechanism of T cell unresponsiveness in cancer driven by the up-regulation of the transcription factor Forkhead box protein P1 (Foxp1), which prevents CD8(+) T cells from proliferating and up-regulatin...

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Hauptverfasser: Stephen, Tom L., Rutkowski, Melanie R., Allegrezza, Michael J., Perales-Puchalt, Alfredo, Tesone, Amelia J., Svoronos, Nikolaos, Nguyen, Jenny M., Sarmin, Fahmida, Borowsky, Mark E., Tchou, Julia, Conejo-Garcia, Jose R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4174366/
https://ncbi.nlm.nih.gov/pubmed/25238097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.08.012
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