Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity

The CD4(+) and CD8(+) T cell dichotomy is essential for effective cellular immunity. How the individual T cell identity is established remains poorly understood. Here we show that the high mobility group (HMG) transcription factors Tcf1 and Lef1 are essential for repressing CD4(+) lineage-associated...

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Pubblicato in:Nat Immunol
Autori principali: Xing, Shaojun, Li, Fengyin, Zeng, Zhouhao, Zhao, Yunjie, Yu, Shuyang, Shan, Qiang, Li, Yalan, Phillips, Farrah C., Maina, Peterson K., Qi, Hank H., Liu, Chengyu, Zhu, Jun, Pope, R. Marshall, Musselman, Catherine A., Zeng, Chen, Peng, Weiqun, “Howard” Xue, Hai-Hui
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873337/
https://ncbi.nlm.nih.gov/pubmed/27111144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3456
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