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Rapamycin ameliorates cadmium-induced activation of MAPK pathway and neuronal apoptosis by preventing mitochondrial ROS inactivation of PP2A

Cadmium (Cd) is a highly toxic metal that affects the central nervous system. Recently we have demonstrated that inhibition of mTOR by rapamycin rescues neuronal cells from Cd-poisoning. Here we show that rapamycin inhibited Cd-induced mitochondrial ROS-dependent neuronal apoptosis. Intriguingly, ra...

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Vydáno v:	Neuropharmacology
Hlavní autoři:	Xu, Chong, Wang, Xiaoxue, Zhu, Yu, Dong, Xiaoqing, Liu, Chunxiao, Zhang, Hai, Liu, Lei, Huang, Shile, Chen, Long
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	2016
Témata:	Article
On-line přístup:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4873321/ https://ncbi.nlm.nih.gov/pubmed/26805420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2016.01.030
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Rapamycin ameliorates cadmium-induced activation of MAPK pathway and neuronal apoptosis by preventing mitochondrial ROS inactivation of PP2A

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