Rapamycin ameliorates cadmium-induced activation of MAPK pathway and neuronal apoptosis by preventing mitochondrial ROS inactivation of PP2A

Cadmium (Cd) is a highly toxic metal that affects the central nervous system. Recently we have demonstrated that inhibition of mTOR by rapamycin rescues neuronal cells from Cd-poisoning. Here we show that rapamycin inhibited Cd-induced mitochondrial ROS-dependent neuronal apoptosis. Intriguingly, ra...

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Publicat a:Neuropharmacology
Autors principals: Xu, Chong, Wang, Xiaoxue, Zhu, Yu, Dong, Xiaoqing, Liu, Chunxiao, Zhang, Hai, Liu, Lei, Huang, Shile, Chen, Long
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873321/
https://ncbi.nlm.nih.gov/pubmed/26805420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2016.01.030
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