Pharmacological targeting of the histone chaperone complex FACT preferentially eliminates glioblastoma stem cells and prolongs survival in preclinical models

The nearly universal recurrence of glioblastoma (GBM) is driven in part by a treatment-resistant subpopulation of GBM stem cells (GSCs). To identify improved therapeutic possibilities, we combined the EGFR/HER2 inhibitor lapatinib with a novel small molecule, CBL0137, which inhibits FACT (Facilitate...

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Pubblicato in:Cancer Res
Autori principali: Dermawan, Josephine Kam Tai, Hitomi, Masahiro, Silver, Daniel J., Wu, Qiulian, Sandlesh, Poorva, Sloan, Andrew E., Purmal, Andrei A., Gurova, Katerina V., Rich, Jeremy N., Lathia, Justin D., Stark, George R., Venere, Monica
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873320/
https://ncbi.nlm.nih.gov/pubmed/26921329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2162
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