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Assessing histidine tags for recruiting deoxyribozymes to catalyze peptide and protein modification reactions()

We evaluate the ability of hexahistidine (His(6)) tags on peptide and protein substrates to recruit deoxyribozymes for modifying those substrates. For two different deoxyribozymes, one that creates tyrosine-RNA nucleopeptides and another that phosphorylates tyrosine side chains, we find substantial...

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Pubblicato in:Org Biomol Chem
Autori principali: Chu, Chih-Chi, Silverman, Scott K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872867/
https://ncbi.nlm.nih.gov/pubmed/27138704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6ob00716c
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