Modification of histidine residues in proteins by reaction with 4-hydroxynonenal.
We find that histidine residues in proteins are major targets for reaction with the lipid peroxidation product 4-hydroxynon-2-enal (HNE). Reaction of insulin (which contains no sulfhydryl groups) with HNE leads to the generation of HNE-protein adducts, which are converted to radioactive derivatives...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1992
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49119/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1584790/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.10.4544 |
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