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Sirtuins as regulators of metabolism and healthspan

Since the beginning of the century, the mammalian sirtuin protein family (SIRT1–SIRT7), has received much attention for their regulatory role, mainly in metabolism and aging. Sirtuins act in different cellular compartments: they deacetylate histones and several transcriptional regulators in the nucl...

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Bibliografiska uppgifter
I publikationen:Nat Rev Mol Cell Biol
Huvudupphovsmän: Houtkooper, Riekelt H., Pirinen, Eija, Auwerx, Johan
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872805/
https://ncbi.nlm.nih.gov/pubmed/22395773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrm3293
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