Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor alpha clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemia.

The characteristic t(15;17) of acute promyelocytic leukemia (APL) fuses the retinoic acid receptor alpha (RAR-alpha) gene on chromosome 17 to a gene on chromosome 15 called PML, a putative transcription factor. This distinct translocation results in a fusion mRNA detected by Northern analysis. Two c...

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Autors principals: Miller, W H, Kakizuka, A, Frankel, S R, Warrell, R P, DeBlasio, A, Levine, K, Evans, R M, Dmitrovsky, E
Format: Artigo
Idioma:Inglês
Publicat: 1992
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC48728/
https://ncbi.nlm.nih.gov/pubmed/1372989
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