Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor alpha clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemia.

The characteristic t(15;17) of acute promyelocytic leukemia (APL) fuses the retinoic acid receptor alpha (RAR-alpha) gene on chromosome 17 to a gene on chromosome 15 called PML, a putative transcription factor. This distinct translocation results in a fusion mRNA detected by Northern analysis. Two c...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Miller, W H, Kakizuka, A, Frankel, S R, Warrell, R P, DeBlasio, A, Levine, K, Evans, R M, Dmitrovsky, E
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48728/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1372989/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.7.2694
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