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Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias

Although acute promyelocytic leukemias (APLs) are consistently associated with a reciprocal chromosome 15;17 translocation, the gene(s) directly affected by the breakpoints have never been isolated. The chromosome 17 breakpoint maps to near the retinoic acid receptor alpha (RAR alpha) locus. Investi...

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Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 1990
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2188762/
https://ncbi.nlm.nih.gov/pubmed/2175343
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