NG2 proteoglycan as a pericyte target for anticancer therapy by tumor vessel infarction with retargeted tissue factor

tTF-TAA and tTF-LTL are fusion proteins consisting of the extracellular domain of tissue factor (TF) and the peptides TAASGVRSMH and LTLRWVGLMS, respectively. These peptides represent ligands of NG2, a surface proteoglycan expressed on angiogenic pericytes and some tumor cells. Here we have expresse...

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Udgivet i:Oncotarget
Main Authors: Brand, Caroline, Schliemann, Christoph, Ring, Janine, Kessler, Torsten, Bäumer, Sebastian, Angenendt, Linus, Mantke, Verena, Ross, Rebecca, Hintelmann, Heike, Spieker, Tilmann, Wardelmann, Eva, Mesters, Rolf M., Berdel, Wolfgang E., Schwöppe, Christian
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872748/
https://ncbi.nlm.nih.gov/pubmed/26735180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6725
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