NOX2 Activation of Natural Killer T Cells Is Blocked by the Adenosine A(2A) Receptor to Inhibit Lung Ischemia–Reperfusion Injury

Rationale: Ischemia–reperfusion (IR) injury after lung transplantation, which affects both short- and long-term allograft survival, involves activation of NADPH oxidase 2 (NOX2) and activation of invariant natural killer T (iNKT) cells to produce IL-17. Adenosine A(2A) receptor (A(2A)R) agonists are...

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Bibliografiske detaljer
Udgivet i:Am J Respir Crit Care Med
Main Authors: Sharma, Ashish K., LaPar, Damien J., Stone, Matthew L., Zhao, Yunge, Mehta, Christopher K., Kron, Irving L., Laubach, Victor E.
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2016
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872653/
https://ncbi.nlm.nih.gov/pubmed/26757359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201506-1253OC
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