Phase I and II Study of Induction Chemotherapy With Methotrexate, Rituximab, and Temozolomide, Followed By Whole-Brain Radiotherapy and Postirradiation Temozolomide for Primary CNS Lymphoma: NRG Oncology RTOG 0227

PURPOSE: This study investigated the treatment of primary CNS lymphoma with methotrexate, temozolomide (TMZ), and rituximab, followed by hyperfractionated whole-brain radiotherapy (hWBRT) and subsequent TMZ. The primary phase I end point was the maximum tolerated dose of TMZ. The primary phase II en...

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Detalhes bibliográficos
Publicado no:J Clin Oncol
Main Authors: Glass, Jon, Won, Minhee, Schultz, Christopher J., Brat, Daniel, Bartlett, Nancy L., Suh, John H., Werner-Wasik, Maria, Fisher, Barbara Jean, Liepman, Marcia K., Augspurger, Mark, Bokstein, Felix, Bovi, Joseph A., Solhjem, Matthew C., Mehta, Minesh P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2016
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872318/
https://ncbi.nlm.nih.gov/pubmed/27022122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2015.64.8634
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