Significant Effect of Polymorphisms in CYP2D6 and ABCC2 on Clinical Outcomes of Adjuvant Tamoxifen Therapy for Breast Cancer Patients

PURPOSE: The clinical efficacy of tamoxifen is suspected to be influenced by the activity of drug-metabolizing enzymes and transporters involved in the formation, metabolism, and elimination of its active forms. We investigated relationships of polymorphisms in transporter genes and CYP2D6 to clinic...

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Veröffentlicht in:J Clin Oncol
Hauptverfasser: Kiyotani, Kazuma, Mushiroda, Taisei, Imamura, Chiyo K., Hosono, Naoya, Tsunoda, Tatsuhiko, Kubo, Michiaki, Tanigawara, Yusuke, Flockhart, David A., Desta, Zeruesenay, Skaar, Todd C., Aki, Fuminori, Hirata, Koichi, Takatsuka, Yuichi, Okazaki, Minoru, Ohsumi, Shozo, Yamakawa, Takashi, Sasa, Mitsunori, Nakamura, Yusuke, Zembutsu, Hitoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Clinical Oncology 2010
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872305/
https://ncbi.nlm.nih.gov/pubmed/20124171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.25.7246
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