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DNA motifs determining the accuracy of repeat duplication during CRISPR adaptation in Haloarcula hispanica

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPRs) acquire new spacers to generate adaptive immunity in prokaryotes. During spacer integration, the leader-preceded repeat is always accurately duplicated, leading to speculations of a repeat-length ruler. Here in Haloarcula hispanica,...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Wang, Rui, Li, Ming, Gong, Luyao, Hu, Songnian, Xiang, Hua
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872114/
https://ncbi.nlm.nih.gov/pubmed/27085805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw260
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