Using structural-based protein engineering to modulate the differential inhibition effects of SAUGI on human and HSV uracil DNA glycosylase

Uracil-DNA glycosylases (UDGs) are highly conserved proteins that can be found in a wide range of organisms, and are involved in the DNA repair and host defense systems. UDG activity is controlled by various cellular factors, including the uracil-DNA glycosylase inhibitors, which are DNA mimic prote...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Wang, Hao-Ching, Ho, Chun-Han, Chou, Chia-Cheng, Ko, Tzu-Ping, Huang, Ming-Fen, Hsu, Kai-Cheng, Wang, Andrew H.-J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2016
Soggetti:
Structural Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872100/
https://ncbi.nlm.nih.gov/pubmed/26980279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw185
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