More than 10% of yeast genes are related to genome stability and influence cellular senescence via rDNA maintenance

Genome instability triggers cellular senescence and is a common cause of cancer. The ribosomal RNA genes (rDNA), due to their repetitive structure, form a fragile site with frequent rearrangements. To identify eukaryotic factors that connect reduced genome stability to senescence we screened 4,876 s...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Saka, Kimiko, Takahashi, Akihiro, Sasaki, Mariko, Kobayashi, Takehiko
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872092/
https://ncbi.nlm.nih.gov/pubmed/26912831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw110
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