Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform

Epigenetic modifications of histone tails play an essential role in the regulation of eukaryotic transcription. Writer and eraser enzymes establish and maintain the epigenetic code by creating or removing posttranslational marks. Specific binding proteins, called readers, recognize the modifications...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Wagner, Tobias, Greschik, Holger, Burgahn, Teresa, Schmidtkunz, Karin, Schott, Anne-Kathrin, McMillan, Joel, Baranauskienė, Lina, Xiong, Yan, Fedorov, Oleg, Jin, Jian, Oppermann, Udo, Matulis, Daumantas, Schüle, Roland, Jung, Manfred
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
Témata:
Methods Online
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872087/
https://ncbi.nlm.nih.gov/pubmed/26893353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw089
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