Structure-Based Design, Docking and Binding Free Energy Calculations of A366 Derivatives as Spindlin1 Inhibitors

The chromatin reader protein Spindlin1 plays an important role in epigenetic regulation, through which it has been linked to several types of malignant tumors. In the current work, we report on the development of novel analogs of the previously published lead inhibitor A366. In an effort to improve...

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Udgivet i:Int J Mol Sci
Main Authors: Luise, Chiara, Robaa, Dina, Regenass, Pierre, Maurer, David, Ostrovskyi, Dmytro, Seifert, Ludwig, Bacher, Johannes, Burgahn, Teresa, Wagner, Tobias, Seitz, Johannes, Greschik, Holger, Park, Kwang-Su, Xiong, Yan, Jin, Jian, Schüle, Roland, Breit, Bernhard, Jung, Manfred, Sippl, Wolfgang
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8199216/
https://ncbi.nlm.nih.gov/pubmed/34072837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22115910
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