Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors

RAD52 is a member of the homologous recombination (HR) pathway that is important for maintenance of genome integrity. While single RAD52 mutations show no significant phenotype in mammals, their combination with mutations in genes that cause hereditary breast cancer and ovarian cancer like BRCA1, BR...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Huang, Fei, Goyal, Nadish, Sullivan, Katherine, Hanamshet, Kritika, Patel, Mikir, Mazina, Olga M., Wang, Charles X., An, W. Frank, Spoonamore, James, Metkar, Shailesh, Emmitte, Kyle A., Cocklin, Simon, Skorski, Tomasz, Mazin, Alexander V.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872086/
https://ncbi.nlm.nih.gov/pubmed/26873923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw087
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