Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors

RAD52 is a member of the homologous recombination (HR) pathway that is important for maintenance of genome integrity. While single RAD52 mutations show no significant phenotype in mammals, their combination with mutations in genes that cause hereditary breast cancer and ovarian cancer like BRCA1, BR...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Huang, Fei, Goyal, Nadish, Sullivan, Katherine, Hanamshet, Kritika, Patel, Mikir, Mazina, Olga M., Wang, Charles X., An, W. Frank, Spoonamore, James, Metkar, Shailesh, Emmitte, Kyle A., Cocklin, Simon, Skorski, Tomasz, Mazin, Alexander V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2016
Soggetti:
Genome Integrity, Repair and Replication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872086/
https://ncbi.nlm.nih.gov/pubmed/26873923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw087
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