Knock-in of large reporter genes in human cells via CRISPR/Cas9-induced homology-dependent and independent DNA repair

CRISPR/Cas9-induced site-specific DNA double-strand breaks (DSBs) can be repaired by homology-directed repair (HDR) or non-homologous end joining (NHEJ) pathways. Extensive efforts have been made to knock-in exogenous DNA to a selected genomic locus in human cells; which, however, has focused on HDR...

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Publicat a:Nucleic Acids Res
Autors principals: He, Xiangjun, Tan, Chunlai, Wang, Feng, Wang, Yaofeng, Zhou, Rui, Cui, Dexuan, You, Wenxing, Zhao, Hui, Ren, Jianwei, Feng, Bo
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2016
Matèries:
Methods Online
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872082/
https://ncbi.nlm.nih.gov/pubmed/26850641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw064
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