ABCA7 frameshift deletion associated with Alzheimer disease in African Americans

OBJECTIVE: To identify a causative variant(s) that may contribute to Alzheimer disease (AD) in African Americans (AA) in the ATP-binding cassette, subfamily A (ABC1), member 7 (ABCA7) gene, a known risk factor for late-onset AD. METHODS: Custom capture sequencing was performed on ∼150 kb encompassin...

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Publicado no:Neurol Genet
Main Authors: Cukier, Holly N., Kunkle, Brian W., Vardarajan, Badri N., Rolati, Sophie, Hamilton-Nelson, Kara L., Kohli, Martin A., Whitehead, Patrice L., Dombroski, Beth A., Van Booven, Derek, Lang, Rosalyn, Dykxhoorn, Derek M., Farrer, Lindsay A., Cuccaro, Michael L., Vance, Jeffery M., Gilbert, John R., Beecham, Gary W., Martin, Eden R., Carney, Regina M., Mayeux, Richard, Schellenberg, Gerard D., Byrd, Goldie S., Haines, Jonathan L., Pericak-Vance, Margaret A.
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871806/
https://ncbi.nlm.nih.gov/pubmed/27231719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/NXG.0000000000000079
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