Compression regulates gene expression of chondrocytes through HDAC4 nuclear relocation via PP2A-depended HDAC4 dephosphorylation

Biomechanics play a critical role in the modulation of chondrocyte function. The mechanisms by which mechanical loading is transduced into intracellular signals that regulate chondrocyte gene expression remain largely unknown. Histone deacetylase 4 (HDAC4) is specifically expressed in chondrocytes....

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Bibliographic Details
Published in:Biochim Biophys Acta
Main Authors: Chen, Chongwei, Wei, Xiaochun, Wang, Shaowei, Jiao, Qiang, Zhang, Yang, Du, Guoqing, Wang, Xiaohu, Wei, Fangyuan, Zhang, Jianzhong, Wei, Lei
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871159/
https://ncbi.nlm.nih.gov/pubmed/27106144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2016.04.018
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