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Mitogen-activated Protein Kinase p38 Induces HDAC4 Degradation in Hypertrophic Chondrocytes
Histone deacetylase 4 (HDAC4) is a critical negative regulator for chondrocyte hypertrophy by binding to and inhibiting Runx2, a critical transcription factor for chondrocyte hypertrophy. It is unclear how HDAC4 expression and stability are regulated during growth plate development. We report here t...
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| Foilsithe in: | Biochim Biophys Acta |
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| Main Authors: | , , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2014
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4289442/ https://ncbi.nlm.nih.gov/pubmed/25447540 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2014.11.003 |
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