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How should we measure proportionality on relative gene expression data?

Correlation is ubiquitously used in gene expression analysis although its validity as an objective criterion is often questionable. If no normalization reflecting the original mRNA counts in the cells is available, correlation between genes becomes spurious. Yet the need for normalization can be byp...

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Detalhes bibliográficos
Publicado no:Theory Biosci
Main Authors: Erb, Ionas, Notredame, Cedric
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4870310/
https://ncbi.nlm.nih.gov/pubmed/26762323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12064-015-0220-8
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