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How should we measure proportionality on relative gene expression data?

Correlation is ubiquitously used in gene expression analysis although its validity as an objective criterion is often questionable. If no normalization reflecting the original mRNA counts in the cells is available, correlation between genes becomes spurious. Yet the need for normalization can be byp...

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Podrobná bibliografie
Vydáno v:Theory Biosci
Hlavní autoři: Erb, Ionas, Notredame, Cedric
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4870310/
https://ncbi.nlm.nih.gov/pubmed/26762323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12064-015-0220-8
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