Fatty Acid Metabolic Defects and Right Ventricular Lipotoxicity in Human Pulmonary Arterial Hypertension

BACKGROUND: The mechanisms of right ventricular (RV) failure in pulmonary arterial hypertension (PAH) are poorly understood. Abnormalities in fatty acid (FA) metabolism have been described in experimental models of PAH, but systemic and myocardial FA metabolism have not been studied in human PAH. ME...

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Veröffentlicht in:Circulation
Hauptverfasser: Brittain, Evan L., Talati, Megha, Fessel, Joshua P., Zhu, He, Penner, Niki, Calcutt, M. Wade, West, James, Funke, Mitch, Lewis, Gregory D., Gerszten, Robert E., Hamid, Rizwan, Pugh, Meredith E., Austin, Eric D., Newman, John H., Hemnes, Anna R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4870107/
https://ncbi.nlm.nih.gov/pubmed/27006481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.115.019351
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