mTORC1 Coordinates Protein Synthesis and Immunoproteasome Formation via PRAS40 to Prevent Accumulation of Protein Stress

Reduction of translational fidelity often occurs in cells with high rates of protein synthesis, generating defective ribosomal products. If not removed, such aberrant proteins can be a major source of cellular stress causing human diseases. Here, we demonstrate that mTORC1 promotes the formation of...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Yun, Young Sung, Kim, Kwan Hyun, Tschida, Barbara, Sachs, Zohar, Noble-Orcutt, Klara E., Moriarity, Branden S., Ai, Teng, Ding, Rui, Williams, Jessica, Chen, Liqiang, Largaespada, David, Kim, Do-Hyung
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4870089/
https://ncbi.nlm.nih.gov/pubmed/26876939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.01.013
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