Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1

Mechanistic target of rapamycin complex 1 (mTORC1), necessary for cellular growth, is regulated by intracellular signaling mediating inhibition of mTORC1 activation. Among mTORC1 regulatory binding partners, the role of Proline Rich AKT Substrate of 40 kDa (PRAS40) in controlling mTORC1 activity and...

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Autori principali: Völkers, Mirko, Toko, Haruhiro, Doroudgar, Shirin, Din, Shabana, Quijada, Pearl, Joyo, Anya Y., Ornelas, Luis, Joyo, Eri, Thuerauf, Donna J., Konstandin, Mathias H., Gude, Natalie, Glembotski, Christopher C., Sussman, Mark A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732982/
https://ncbi.nlm.nih.gov/pubmed/23842089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301455110
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