PRAS40 suppresses atherogenesis through inhibition of mTORC1-dependent pro-inflammatory signaling in endothelial cells

Endothelial pro-inflammatory activation plays a pivotal role in atherosclerosis, and many pro-inflammatory and atherogenic signals converge upon mechanistic target of rapamycin (mTOR). Inhibitors of mTOR complex 1 (mTORC1) reduced atherosclerosis in preclinical studies, but side effects including in...

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Vydáno v:Sci Rep
Hlavní autoři: Zhang, Kevin Sun, Schecker, Johannes, Krull, Alexandros, Riechert, Eva, Jürgensen, Lonny, Kamuf-Schenk, Verena, Burghaus, Jana, Kiper, Leon, Cao Ho, Thanh, Wöltje, Kerstin, Stangl, Verena, Katus, Hugo A., Stangl, Karl, Völkers, Mirko, Althoff, Till F.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6856095/
https://ncbi.nlm.nih.gov/pubmed/31728028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53098-1
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