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Dominant-negative Gα subunits are a mechanism of dysregulated heterotrimeric G protein signaling in human disease
Auriculo-Condylar Syndrome (ACS), a rare condition that impairs craniofacial development, is caused by mutations in a G protein-coupled receptor (GPCR) signaling pathway. In mice, disruption of signaling by the endothelin type A receptor (ET(A)R), which is mediated by the G protein subunit Gα(q/11)...
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| Опубликовано в: : | Sci Signal |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4870087/ https://ncbi.nlm.nih.gov/pubmed/27072656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aad2429 |
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