Bioenergetic deficits in peripheral nerve sensory axons during chemotherapy-induced neuropathic pain resulting from peroxynitrite-mediated post-translational nitration of mitochondrial superoxide dismutase

Many of the widely used anticancer drugs induce dose-limiting peripheral neuropathies that undermine their therapeutic efficacy. Animal models of chemotherapy-induced painful peripheral neuropathy (CIPN) evoked by a variety of drug classes, including taxanes, vinca alkaloids, platinum-complexes, and...

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Publicado en:Pain
Autores principales: Janes, Kali, Doyle, Timothy, Bryant, Leesa, Esposito, Emanuela, Cuzzocrea, Salvatore, Ryerse, Jan, Bennett, Gary J., Salvemini, Daniela
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4870004/
https://ncbi.nlm.nih.gov/pubmed/23891899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2013.07.032
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