Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival

The absence of Bmal1, a core clock gene, results in a loss of circadian rhythms, an acceleration of aging, and a shortened life span in mice. To address the importance of circadian rhythms in the aging process, we generated conditional Bmal1 knockout mice that lacked the BMAL1 protein during adult l...

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Bibliographic Details
Published in:Sci Transl Med
Main Authors: Yang, Guangrui, Chen, Lihong, Grant, Gregory R., Paschos, Georgios, Song, Wen-Liang, Musiek, Erik S., Lee, Vivian, McLoughlin, Sarah C., Grosser, Tilo, Cotsarelis, George, FitzGerald, Garret A.
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4870001/
https://ncbi.nlm.nih.gov/pubmed/26843191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aad3305
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