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Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival
The absence of Bmal1, a core clock gene, results in a loss of circadian rhythms, an acceleration of aging, and a shortened life span in mice. To address the importance of circadian rhythms in the aging process, we generated conditional Bmal1 knockout mice that lacked the BMAL1 protein during adult l...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Sci Transl Med |
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| Κύριοι συγγραφείς: | , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2016
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4870001/ https://ncbi.nlm.nih.gov/pubmed/26843191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aad3305 |
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