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Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival
The absence of Bmal1, a core clock gene, results in a loss of circadian rhythms, an acceleration of aging, and a shortened life span in mice. To address the importance of circadian rhythms in the aging process, we generated conditional Bmal1 knockout mice that lacked the BMAL1 protein during adult l...
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| Publicado no: | Sci Transl Med |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4870001/ https://ncbi.nlm.nih.gov/pubmed/26843191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aad3305 |
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