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Proline-rich tyrosine kinase 2 downregulates peroxisome proliferator–activated receptor gamma to promote hypoxia-induced pulmonary artery smooth muscle cell proliferation

Abstract. Hypoxia stimulates pulmonary hypertension (PH), in part by increasing the proliferation of human pulmonary artery smooth muscle cells (HPASMCs) via sustained activation of mitogen-activated protein kinase, extracellular signal–regulated kinases 1 and 2 (ERK 1/2), and nuclear factor-kappa B...

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Bibliographic Details
Published in:Pulm Circ
Main Authors: Bijli, Kaiser M., Kang, Bum-Yong, Sutliff, Roy L., Hart, C. Michael
Format: Artigo
Language:Inglês
Published: University of Chicago Press 2016
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869925/
https://ncbi.nlm.nih.gov/pubmed/27252847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/686012
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