Compensation for PKMζ in long-term potentiation and spatial long-term memory in mutant mice

PKMζ is a persistently active PKC isoform proposed to maintain late-LTP and long-term memory. But late-LTP and memory are maintained without PKMζ in PKMζ-null mice. Two hypotheses can account for these findings. First, PKMζ is unimportant for LTP or memory. Second, PKMζ is essential for late-LTP and...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Tsokas, Panayiotis, Hsieh, Changchi, Yao, Yudong, Lesburguères, Edith, Wallace, Emma Jane Claire, Tcherepanov, Andrew, Jothianandan, Desingarao, Hartley, Benjamin Rush, Pan, Ling, Rivard, Bruno, Farese, Robert V, Sajan, Mini P, Bergold, Peter John, Hernández, Alejandro Iván, Cottrell, James E, Shouval, Harel Z, Fenton, André Antonio, Sacktor, Todd Charlton
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2016
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869915/
https://ncbi.nlm.nih.gov/pubmed/27187150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.14846
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