Compensation for PKMζ in long-term potentiation and spatial long-term memory in mutant mice

PKMζ is a persistently active PKC isoform proposed to maintain late-LTP and long-term memory. But late-LTP and memory are maintained without PKMζ in PKMζ-null mice. Two hypotheses can account for these findings. First, PKMζ is unimportant for LTP or memory. Second, PKMζ is essential for late-LTP and...

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Foilsithe in:eLife
Main Authors: Tsokas, Panayiotis, Hsieh, Changchi, Yao, Yudong, Lesburguères, Edith, Wallace, Emma Jane Claire, Tcherepanov, Andrew, Jothianandan, Desingarao, Hartley, Benjamin Rush, Pan, Ling, Rivard, Bruno, Farese, Robert V, Sajan, Mini P, Bergold, Peter John, Hernández, Alejandro Iván, Cottrell, James E, Shouval, Harel Z, Fenton, André Antonio, Sacktor, Todd Charlton
Formáid: Artigo
Teanga:Inglês
Foilsithe: eLife Sciences Publications, Ltd 2016
Ábhair:
Neuroscience
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869915/
https://ncbi.nlm.nih.gov/pubmed/27187150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.14846
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