Compensation for PKMζ in long-term potentiation and spatial long-term memory in mutant mice

PKMζ is a persistently active PKC isoform proposed to maintain late-LTP and long-term memory. But late-LTP and memory are maintained without PKMζ in PKMζ-null mice. Two hypotheses can account for these findings. First, PKMζ is unimportant for LTP or memory. Second, PKMζ is essential for late-LTP and...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Tsokas, Panayiotis, Hsieh, Changchi, Yao, Yudong, Lesburguères, Edith, Wallace, Emma Jane Claire, Tcherepanov, Andrew, Jothianandan, Desingarao, Hartley, Benjamin Rush, Pan, Ling, Rivard, Bruno, Farese, Robert V, Sajan, Mini P, Bergold, Peter John, Hernández, Alejandro Iván, Cottrell, James E, Shouval, Harel Z, Fenton, André Antonio, Sacktor, Todd Charlton
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2016
Assuntos:
Neuroscience
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869915/
https://ncbi.nlm.nih.gov/pubmed/27187150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.14846
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