Design, Synthesis, and Chemical and Biological Properties of Cyclic ADP-4-Thioribose as a Stable Equivalent of Cyclic ADP-Ribose

Here we describe the successful synthesis of cyclic ADP-4-thioribose (cADPtR, 3), designed as a stable mimic of cyclic ADP-ribose (cADPR, 1), a Ca(2+)-mobilizing second messenger, in which the key N1-β-thioribosyladenosine structure was stereoselectively constructed by condensation between the imida...

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Publicado no:Messenger (Los Angel)
Main Authors: Tsuzuki, Takayoshi, Takano, Satoshi, Sakaguchi, Natsumi, Kudoh, Takashi, Murayama, Takashi, Sakurai, Takashi, Hashii, Minako, Higashida, Haruhiro, Weber, Karin, Guse, Andreas H., Kameda, Tomoshi, Hirokawa, Takatsugu, Kumaki, Yasuhiro, Arisawa, Mitsuhiro, Potter, Barry V. L., Shuto, Satoshi
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869844/
https://ncbi.nlm.nih.gov/pubmed/27200225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1166/msr.2014.1035
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