Negative Ions Enhance Survival of Membrane Protein Complexes

Membrane protein complexes are commonly introduced to the mass spectrometer solubilized in detergent micelles. The collisional activation used to remove the detergent, however, often causes protein unfolding and dissociation. As in the case for soluble proteins, electrospray in the positive ion mode...

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Detalhes bibliográficos
Publicado no:J Am Soc Mass Spectrom
Main Authors: Liko, Idlir, Hopper, Jonathan T. S., Allison, Timothy M., Benesch, Justin L. P., Robinson, Carol V.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2016
Assuntos:
Focus: Mass Spectrometry as a Probe of Higher Order Protein Structure: Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869745/
https://ncbi.nlm.nih.gov/pubmed/27106602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13361-016-1381-5
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