Safety, tolerability, pharmacokinetics, and pharmacodynamics of novel glucokinase activator HMS5552: results from a first-in-human single ascending dose study

BACKGROUND: HMS5552, a novel fourth-generation glucokinase (GK) activator, has demonstrated promising effects on glycemic control in preclinical models of type 2 diabetes. This single ascending dose study was conducted to investigate the safety, tolerability, pharmacokinetics (PK), and pharmacodynam...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Drug Des Devel Ther
Hauptverfasser: Xu, Hongrong, Sheng, Lei, Chen, Weili, Yuan, Fei, Yang, Mengjie, Li, Hui, Li, Xuening, Choi, John, Zhao, Guiyu, Hu, Tianxin, Li, Yongguo, Zhang, Yi, Chen, Li
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2016
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869670/
https://ncbi.nlm.nih.gov/pubmed/27274195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S105021
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge