Safety, tolerability, pharmacokinetics, and pharmacodynamics of novel glucokinase activator HMS5552: results from a first-in-human single ascending dose study

BACKGROUND: HMS5552, a novel fourth-generation glucokinase (GK) activator, has demonstrated promising effects on glycemic control in preclinical models of type 2 diabetes. This single ascending dose study was conducted to investigate the safety, tolerability, pharmacokinetics (PK), and pharmacodynam...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Xu, Hongrong, Sheng, Lei, Chen, Weili, Yuan, Fei, Yang, Mengjie, Li, Hui, Li, Xuening, Choi, John, Zhao, Guiyu, Hu, Tianxin, Li, Yongguo, Zhang, Yi, Chen, Li
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869670/
https://ncbi.nlm.nih.gov/pubmed/27274195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S105021
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