Serial image analysis of Mycobacterium tuberculosis colony growth reveals a persistent subpopulation in sputum during treatment of pulmonary TB

Faster elimination of drug tolerant ‘persister’ bacteria may shorten treatment of tuberculosis (TB) but no method exists to quantify persisters in clinical samples. We used automated image analysis to assess whether studying growth characteristics of individual Mycobacterium tuberculosis colonies fr...

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Bibliographische Detailangaben
Veröffentlicht in:Tuberculosis (Edinb)
Hauptverfasser: Barr, David A., Kamdolozi, Mercy, Nishihara, Yo, Ndhlovu, Victor, Khonga, Margaret, Davies, Geraint R., Sloan, Derek J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Churchill Livingstone 2016
Schlagworte:
Drug Discovery and Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869592/
https://ncbi.nlm.nih.gov/pubmed/27156626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tube.2016.03.001
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