An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology

G protein-coupled receptors are allosteric proteins that control transmission of external signals to regulate cellular response. Although agonist binding promotes canonical G protein signalling transmitted through conformational changes, G protein-coupled receptors also interact with other proteins....

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Опубликовано в: :Cell Discov
Главные авторы: J Gingell, Joseph, Simms, John, Barwell, James, Poyner, David R, Watkins, Harriet A, Pioszak, Augen A, Sexton, Patrick M, Hay, Debbie L
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869360/
https://ncbi.nlm.nih.gov/pubmed/27462459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2016.12
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